THE TREPONEMA PALLIDUM

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Shape of Treponema pallidum.

Treponema pallidum was found to be not helical, but a flat wave twisted into one to five different planes per cell.

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Mucopolysaccharidase of Treponema pallidum.

Treponema pallidum (Nichols strain) exhibited mucopolysaccharidase activity. Acidic mucopolysaccharides were broken down more rapidly by viable treponemes than by heat-inactivated treponemes or membrane filtrates of treponemal suspensions. Ouchterlony immunodiffusion demonstrated the occurrence of antibodies to the hyaluronidase-like enzyme within syphilitic sera. After intratesticular inoculat...

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Treponema pallidum in nerve fibres.

Ultrathin sections of a rabbit scrotal syphiloma were examined by electron microscopy. Treponemes were observed in the endo-, peri-, and epineurium of the nerve fibre. The significance of these findings, in that infection may be transmitted via the nerve fibres and pain reduced by damage to the afferent fibres, are discussed.

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Oxygen uptake by Treponema pallidum.

Virulent Treponema pallidum has been shown to consume O(2) at a rate similar to that of the known aerobic spirochaete, Leptospira. Such O(2) uptake is cyanide sensitive, indicating a functioning cytochrome oxidase. Inhibition of O(2) uptake by azide, chlorpromazine, and amytal further suggests a functioning electron transport system for the oxidation of nicotinamide adenine dinucleotide (reduce...

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Concerning Agglutinins for Treponema Pallidum

1. There is no demonstrable amount of agglutinin for Treponema pallidum (Noguchi) in normal human and normal rabbit serum in dilutions as low as 1:20. 2. Agglutinins for Treponema pallidum are readily produced in young rabbits by the administration of pure cultures of living spirochetes. 3. There is no appreciable amount of agglutinin for Treponema pallidum culture used in the sera of secondary...

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ژورنال

عنوان ژورنال: Archives of Internal Medicine

سال: 1909

ISSN: 0730-188X

DOI: 10.1001/archinte.1909.00050160040002